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This application is for renewal of the T32 comprehensive institutional research-training grantCOSTAR (Craniofacial Oral-Biology Student Training in Academic Research). Building onlongstanding institutional research training experience, COSTAR has trained 26 DDS/PhDstudents, 41 PhD students, 26 Post-doctoral Fellows, 4 faculty fellows, and 147 summer dentalstudent research fellows since first funded in 2002.

UT Health San Antonio
Hargreaves, Kenneth M

Myelodysplastic syndrome (MDS) is a group of disorders characterized by dysfunctional blood cells that can progress to acute myeloid leukemia (AML). At this time the etiology of MDS development and progression to AML is not understood and there is no cure (median survival at time of diagnosis is less than 5 years). Yet, DNA damage and mutations appear to play a key role with the initiating defect in a hematopoietic stem cell (HSC). In support, people with certain DNA repair defective syndromes including Fanconi anemia (FA) and Bloom syndrome (BS) exhibit MDS.

UT Health San Antonio
Hasty, Edward Paul