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The primary objective of this study is to determine the safety and effectiveness of AmnioFix Injectable as compared to the 0.9% Sodium Chloride Injection, USP placebo control for the treatment of knee osteoarthritis.

Brooke Army Medical Center
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Activation of the oncogene MYC is a frequent event in multiple myeloma (MM) that contributes to refractory/high-risk disease and is therefore an attractive therapeutic target. We previously demonstrated that a novel reovirus formulation for cancer therapy called Reolysin is a promising new agent for patients with MM as it exhibits significant activity in cell lines, primary patient cells, and mouse models of the disease. However, the mechanisms that mediate reovirus sensitivity in MM cells are not well understood.

UT Health San Antonio
Nawrocki, Steffan T