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This renewal application requests 3 years of support to continue a highly successful international scientific meeting entitled Behavior, Biology and Chemistry: Translational Research in Addiction (BBC) that has been held annually in San Antonio Texas since 2009. In addition to this grant as well as a previous NIH grant, BBC meetings have received significant financial and institutional support from the University of Texas Health Science Center at San Antonio and several other universities.

UT Health San Antonio
France, Charles P

Burns often lead to persistent pain not well managed by available analgesics. The mechanisms of burn pain are incompletely understood. However, the TRPV1 (transient receptor potential V1) receptor appears to be pivotally involved in post-burn pain. In our preliminary data, ~67% of post-burn thermal hyperalgesia is blocked by peripheral injection of a TRPV1 receptor antagonist. In addition, extracts of burned human skin produce thermal hyperalgesia when injected into rats via a TRPV1 receptor mechanism.

UT Health San Antonio
Hargreaves, Kenneth M.