Facilitated By

San Antonio Medical Foundation

Role of Antigen-Specific T Cell Responses in the Control of TB

Texas Biomedical Research Institute

 

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Principal Investigator(s)
Kaushal, Deepak
Collaborating Institutions
Emory University
Funded by
National Institutes of Health
Research Start Date
Status
Active

19-053 The major goal is to develop reagents for and to identify antigen-specific T cell responses in macaques with persistent and cured LTBI. In the first three years of this program project we have infected 12 macaques with ultra low-dose of Mtb to generate LTBI, and developed a model for LTBI clearance by treating half the animals with INH/RIF weekly regimen for 12 weeks. We will now study correlates of clearance in INH/RIF treated and untreated animals using banked PBMCs, stimulated BAL and lung cell samples. Antigen-specificity will be evaluated using a complex panel of 60 Mtb antigens. Role: Sub-PI

Collaborative Project
Basic Research
Disease Modeling
Infectious Disease