Bone fragility fractures are a major concern of health care of rapidly aging populations due to the high
risk of long-term disability and even mortality. Such fractures are not only due to loss of bone mineral density
(BMD), but also due to adverse changes at different structural hierarchies of bone, including ultrastructural
changes observed in bone disorders (e.g. osteogenesis imperfecta, mucopolysaccharidosis, and age-related