This is a multinational, multicenter, randomized, open-label, parallel-group Phase 3 study. The primary objective is to compare the efficacy of tesetaxel plus a reduced dose of capecitabine versus the approved dose of capecitabine alone based on progression-free survival (PFS), as assessed by an Independent Radiologic Review Committee (IRC), in patients with HER2 negative, HR positive MBC previously treated with a taxane in the neoadjuvant or adjuvant setting.