Southwest Research Institute (SwRI), headquartered in San Antonio, Texas, is one of the oldest and largest independent, nonprofit, applied research and development (R&D) organizations in the United States.
Principal Investigator(s)
Xingguo Cheng
Robert J. Christy
Denis Feliers
Funded by
San Antonio Medical Foundation
Collaborating Institutions
US Army Institute of Surgical Research
The University of Texas Health Science Center at San Antonio
This project aims to develop a new stem cell-based therapy for non-healing diabetic ulcers using a full-thickness skin defect animal model of type 2 diabetes. Bioactive cell sheets based on electrochemically aligned collagen matrix combined with ADSCs will be used to treat chronic, non-healing wounds.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Lai, Zhao
Funded by
NIH
DESCRIPTION (provided by applicant) Funds are requested to purchase an Illumina HiSeq 3000 Sequencer for the Genome Sequencing Facility (GSF) of Greehey Children's Cancer Research Institute (GCCRI) at the University of Texas Health Science Center at San Antonio (UTHSCSA). At the present time, high throughput sequencing is conducted on a heavily utilized Illumina HiSeq 2000 sequencer that was purchased in December 2010, and there were no other publicly accessible high-throughput NGS platforms within UTHSCSA and surrounding San Antonio institutions.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Anderson, Timothy J. C.
Funded by
NIH-PMS
Collaborating Institutions
UTHSCSA
Kenya Medical Research Institute
Ministry of Health-Kampala Uganda
Treatment with a monotherapy (praziquantel (PZQ)) is the basis for control of parasite flukes in the genus Schistosoma, but imposes strong selection for resistance in the parasite population. This project will identify genes underlying PZQ resistance in parasites selected in the laboratory and in parasites that survive PZQ treatment in patients in order to (i) provide genetic markers for monitoring resistance evolution in the treatment programs and (ii) better understand the mode of action and mechanism of resistance.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ipson, Brett
Funded by
NIH
Oxidative stress increases with age and likely contributes to a variety of age-related diseases, but the processes by which oxidative stress causes cellular damage and contributes to aging and its associated pathologies are not completely understood. This proposal seeks to study the role of atypical tyrosine isomers, which differ from endogenous tyrosine in the positioning of their hydroxyl group on the benzyl ring, in the harmful effects of oxidative stress.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Cole, Shelley A.
Funded by
University of North Carolina
The purpose of this project is to design the scientific approaches, collect the appropriate molecular genetic data, develop manuscripts of the results generated from this study and conduct the administrative activities needed for its successful completion of genotyping up to 960 single nucleotide variants (SNV) in candidate genes affecting type 2 diabetes and chronic kidney disease in up to 460 Strong Heart participants’ DNA samples.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Defronzo, Ralph A
Funded by
NIH
Hyperglycemia is the major risk factor for the development of diabetic microvascular complications. The ADA recommends lowering the A1c in T2DM individuals to levels (i.e. HbA1c <6.0-6.5%) 'as close to normal as possible while avoiding hypoglycemia'. The optimal pharmacologic therapy which achieves this goal never has been determined.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ayala, Iriscilla Imabary
Funded by
NIH
Type 2 diabetes (T2D) affects approximately 8.3% of the United States population. Family history is one of the major risk factors for T2D noncoding genetic variation in the transcription factor 7-like 2 (TCF7L2) gene is significantly associated with T2D in multiple ethnic populations, yet the biological mechanism(s) that lead to increased risk are still unclear. Evidence for involvement of the central nervous system (CNS) in regulating fasting and postprandial glucose levels continues to grow, and TCF7L2 localization in the hypothalamus suggests a potential role in glucose regulation.