Acquisition and deployment of the CrimeEye video surveillance system with Genetec video analytics that will allow our security team to maximize their efforts to keep our campus secure by having better situational awareness through enhanced monitoring, verification and validation of threats improving security response times.

The goal is to have immediate impact by identifying prophylactic/therapeutic interventions using micronutrients as effective, low-cost, low-risk countermeasures to reduce viral damage to human airway cells and mitigate virus spread during this pandemic. The impact of our focus on ?epithelial defense? will provide an immediate means to fortify airway epithelial barrier function early during SARS-CoV-2 illness, which will reduce lung water accumulation and dyspnea in infected patients.

For this proposal, we will be responsible for the experiments involving infection of K18 hACE2 mice with SARS-CoV-2 USA-WA1/2020 strain and assess the effectivity of a drug compound provided by the partnering company.

PROJECT SUMMARY
 Interrogation of basic biological phenomena in the post-genome era relies heavily on high-throughput. sensitive technologies that provide molecular profiles of cells and tissues. High-dimensionality molecular measurements (e.g.. levels of mRNAs for many/all genes) can be readily accomplished in bulk samples and down to the single-cell level. producing comprehensive (???omics) profiles for given samples that address research needs. However. such techniques necessarily ignore the tissue localization of gene products in order to produce the high-dimensionality data.

This major goal of this funding is to outfit the Pathology Unit of SNPRC with a new chemistry analyzer, a new slide stainer and coverslipper, as well as seeks to purchase a state of the art whole slide scanner, which will provide a significant upgrade to research capabilities supported by Texas Biomed.

The major goal of this study is to evaluate the cellular immune response in macaques vaccinated with an anti-heme vaccine.

Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes acute Q fever and chronic infections in humans. Since there is no licensed vaccine for prevention of human Q fever in the US. the development of safe and effective prophylactic and therapeutic strategies for controlling C. burnetii infection remains an important goal for public health. However. there is a fundamental gap in the knowledge regarding the mechanisms of host immune response to C. burnetii natural infection.