This collaborative research will combine skills to optimize methodology to facilitate germline transmission of edited ARX alleles and to generate genetic tools useful to all marmoset researchers. including germline transmitted germ cell and neuronal reporter transgenes. and neuronal Cre drivers via the following three specific aims: 
 
 Neurological disorders have seen a dismal rate of new therapies despite promising findings in rodents. arguably due to problems translating these findings to the clinic. The human cortex features larger superficial layers.

Many commonly prescribed chemotherapy drugs have adverse side effects that include disruptions in taste. It is reported that 50-80% of cancer patients who receive chemotherapy treatments experience taste alteration in the form of reduced taste sensitivity. distorted taste perception. or even complete loss of taste during treatment1-5. These deficits can persist for months beyond the end of therapy. Indeed. the side effects of chemotherapy on taste is listed as one of the most disturbing elements of treatment.

Hearing protection devices (HPDs) are standard personal protective equipment (PPE). but servicemembers often do not use them because HPDs impair spatial hearing. which compromises situation awareness. Here we will quantify the impact of a passive HPD on spatial hearing and motion perception. and test if a 3-day augmented reality training regime induces plasticity leading to significant improvements. Attention profoundly influences auditory processing. and is expected to facilitate training-related plasticity.

In the United States. English is the primary language of instruction and testing in most schools.
 However. many bilingual students entering US schools learned foundational concepts in a language other than English and might be at a developmental disadvantage when expected to build on this knowledge. It has been widely debated in the literature which concepts are stored as language-specific memories and how bilinguals might access this information in their other language. In this proposal.

The San Antonio Ligand Consortium (SALC) seeks to develop selective alpha-Synuclein (a-Syn) and 4R tau PET radiotracers for use in Parkinson???s disease (PD). non-Alzheimer???s disease (non-AD) tauopathies and related disorders. This goal is pursued via a tapering pipeline for: tracer design (Aim 1); tracer synthesis. characterization and prioritization (Aim 2); and validation (Aim 3).The overall project is developed to design highly specific 4R tau and a-Syn ligands from design through clinical translation.

This career research project provides the foundation for a long-term productive research program to investigate nanoscale transport phenomena principles for the development of a novel neuromodulation technology. This research explores fundamental questions of nanoscale heat and mass transport. and applies these findings to yield a completely new mechanism to transduce magnetic signals into biochemical stimulus utilizing hybrid nanomaterials. This research would (1) develop a completely new paradigm for precise control of neural activity.

Statistics are staggering: in the U.S. alone. nearly six million affected. sixth most common cause of death. over $300 billion per year in direct care costs and billions more in unpaid care. billions of dollars in research and Alzheimers disease (AD) has no effective therapy to reverse let alone arrest progression. AD is the only common disease increasing every year. Described over a century ago and with thousands of talented researchers studying it. AD has no effective drugs to prevent. treat or cure it. For 20 years I have argued against the dominant theory.

In the U.S. alone, 2.8 million people sustain a traumatic brain injury (TBI) each year and seek medical care.1,2 However, there are no FDA approved therapies for effective treatment of TBI (or concussion) patients. Current medications are limited to only reducing secondary damage to the brain following TBI, such as using diuretics to reduce the pressure inside the brain by increasing urine output.