The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Xiong, Na
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
Collaborating Institutions
PNNL
BATTELLE
EMBL
The skin is the outmost epithelial tissue of a body that is under frequent assaults ofenvironmental agents. To protect against the assaults and maintain the local tissueintegrity, immune cells need to be properly positioned in the skin. A group of immunecells, namely innate lymphoid cells (ILCs), are preferentially localized in the skin wherethey function as the first line of defense but can also contribute to the skin inflammatorydiseases such as topical dermatitis and psoriasis when dysregulated.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ivanov, Dmitri N
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
SAMHD1, a mammalian member of the HD-domain hydrolase family of enzymes, catalyzes hydrolysis ofdeoxynucleotides triphosphates (dNTPs) to triphosphate and unphosphorylated nucleosides, which is thoughtto be the main pathway for controlled depletion of cellular dNTPs. Discoveries that SAMHD1 is an immunefactor that restricts retroviral replication in non-cycling immune cells and regulates interferon signaling revealedthat dNTP depletion may act as a defense mechanism of innate antiviral immunity.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing Chief Scientist provides the strategic vision, direction, oversight, project management support and technical resources to advance medical modernization efforts with a unique focus on research activities.
