The goal of this study is to test the efficacy of novel Monoclonal Antibody Cocktails Against Lethal Challenges of nonhuman Primates with EBOV

The major goal is to test the efficacy of a variety of Antibodies against Ebolavirus challenge.

There is currently no efficient vaccine developed to prevent infection by the Human Immunodeficiency Virus (HIV), the agent responsible for Acquired Immunodeficiency Syndrome (AIDS). Classic vaccine strategies, such as the use of live attenuated viruses, where the immune system is stimulated by exposure of the host organism to non infectious viral particles, have led to safety issues in the case of HIV. We propose to develop a new vaccine strategy that elicits a long-term immunity against HIV infection at the site of entry of the virus in the case of mucosal infection.

The goal of this project is to evaluate the role of DNA epigenetic modifications and their role in mediating the association between arsenic exposure and CVD in participants of the Strong Heart Study (SHS).

The goal is to identify and characterize novel anti-schistosomal drugs to treat this disease.

Currently there is no efficient vaccine developed to prevent transmission of the Human Immunodeficiency Virus (HIV), the agent responsible for Acquired Immunodeficiency Syndrome (AIDS). Classic vaccine strategies, such as the use of live attenuated viruses where the immune system is stimulated by exposure of the host organism to infectious viral particles, have led to safety issues in the case of HIV. The development of an effective vaccine that restricts viral replication at mucosal portals of entry remains our best hop for controlling the HIV pandemic.

Rapidly detecting viral signatures is important in diagnosing Marburg and Ebola viral disease to hasten quarantine, limit the spread of contagion, and contain an outbreak. We have discovered a group of llama derived antibodies that bind to highly conserved regions of a Filoviral polymer, thereby enabling sensitive detection of a broad range of these viruses. Our aim to is to develop these antibodies into streamlined tests designed to detect all Marburg and Ebola strains known and potentially those yet to emerge, helping to safeguard human health both now and into the future.

The goal of this pilot grant is to derive iPSCs from marmosets using the retrovirus and episomal reprogramming techniques, differentiate them into neurons and develop transplantation strategy in marmoset model of Parkinson’s disease.

The goal of this pilot grant is to graft dopaminergic neurons into marmosets and develop MRI and PET imaging techniques to visualize the grafts and dopaminergic innervation.

Infections with malaria parasites frequently contain both multiple Plasmodium species and multiple haplotypes from each species. Multiple species and haplotype infections impact disease severity, the spread of drug resistance and basic population genetic parameters, and complicate even basic genetic analysis. This study applies novel approaches developed in our laboratory which address this problem by generating whole genome sequence from single parasite-infected cells. We will apply these to human infections to refine our understanding of the complexity of malaria infections.