Basic Research

MITRE is planning for and incorporate the latest technology approaches and solutions to defend the Air Force against cyber security threats. UTSA has prioritized cyber security education and research as a major initiative. This SOW leverages MITRE's FFRDC expertise with UTSA's capabilities in cyber
 security and software development.The need to rapidly develop. test and deploy software applications has driven developers to employ agilemethodologies for cyber security systems.

Basic Research

1.SCOPE.This research project processes experimental testing and characterization of suction devices for Excitus AS by Dr. R. Lyle Hood of the Mechanical Engineering Department at the University of Texas at San Antonio (UTSA) and Robert De Lorenzo of the Emergency Medicine Department at the University of Texas Health Science Center in San Antonio.

A significant challenge for in vivo genetic engineering is the transmembrane transport of relatively large genetic payloads. Larger molecules and transcription plasmids typically require viral vectors or permeabilizing agents. which can be challenging to engineer and may have deleterious systemic effects. As an alternative approach. electroporation uses ultrashort electrical pulses to transport large molecules across cell membranes. This approach is advantageous in applications such as delivery of DNA vaccines.

The Center for Innovative Drug Discovery (CIDD) will provide Dr. Min Kang at Texas Tech Health Science Center with medicinal chemistry support to perform custom synthesis and SAR study of narciclasine. as well as the derivatives of high-throughput screening hit Life Chemical E10 chemotype. The CIDD will provide all the necessary services. qualified personnel. materials. equipment and the facilities to ensure the requested tasks are completed. The requested tasks may include the following activities: developing synthesis methods. optimizing reaction conditions.

This is a research subcontract to evaluate the function of a prototype sensor to detect Staphylococcus Enterotoxin B in food matrix.

This proposal addresses developing advanced airway devices for use during respiratory failure and prolonged intubation to deliver therapeutics during intubation for acute respiratory distress syndrome. In a broader context. controlled therapeutic delivery from our endotracheal tube platform may serve a larger role in preventing and treating ventilator associated pneumonia. Our novel ET tube coating provides the additional potential of drug delivery. We propose to employ our existing. novel laryngotracheal models delivering therapeutics to vocal folds.

Fungal infections constitute a major threat to an ever expanding spectrum of immune- and medically-compromised patients. The opportunistic pathogenic fungi Candida spp.. Aspergillus spp. and Cryptococcus neoformans are among the most common etiologic agents of mycoses; but infections caused by other yeasts and moulds are on the rise as advances in modern medicine prolongs lives resulting in increasingly susceptible and vulnerable patients. However. fungi have recently been referred to as the ???hidden killers/the neglected epidemic???

Pb complete liver stage assay