The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Jones, James
Wilson, Charles
Funded by
Natl Inst of Health
The external globus pallidus (GPe) is usually considered simply a relay in the indirect pathway between the striatum and the basal ganglia output neurons in the internal pallidal segment and substantia nigra. This view has been disrupted by recent findings that the GPe contains several different cell types. with different striatal afferents that include the direct pathway. and different downstream targets. and which are interconnected in the GPe by their axon collateral arborizations.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Cardona, Astrid
Funded by
Natl Inst of Health
In the diabetic retina disruption of fractalkine (FKN) signaling induces fibrin(ogen) deposition. increased production of IL-1??? by microglia. vascular and neuronal damage.But. how FKN and its receptor. CX3CR1. regulate microglia activation and retinal pathology is unknown.In humans. two single nucleotide polymorphisms in the CX3CR1 locus (hCX3CR1-I249/M280) that show defective binding to FKN. play a key role in inflammation during diabetes.Induction of diabetes in a mouse model expressing the human CX3CR1-I249/M280 revealed accelerated neuronal loss in the retina.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Han, Hai-Chao
Funded by
UTSA VPR Office
This project will develop a method to obtain the fine structure of trabeculae carneae in human heart and establish a computation human heart model with these fine structure details. it will be a powerful tool to develop a trabecular cutting technique to treat patients with heart failure with preserved ejection fraction.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
McHardy, Stanton
Funded by
Univ of TX MD Anderson Cancer Ctr 506
The Center for Innovative Drug Discovery (CIDD) will provide Dr. Kunal Rai at the University of Texas MD Anderson Cancer Center with the custom synthesis of PROTACs and CIDD-0150877 analogs to support their research on YAP1 degraders. The CIDD will provide the compound design on new analogs to prepare. along with the detailed experimental conditions and analytical data associated with the established synthesis routes. The CIDD will design specific analogs based on the testing results and provide full medicinal chemistry support to optimize compounds. YAP1 potency. selectivity.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Hermann, Brian
Funded by
UTSA VPR Office
Spermatogonial stem cells (SSCs) are required for sperm production and male fertility. but we do not yet understand how activity of these cells is regulated or even precisely where they reside in the seminiferous tubules of the testis. Our previous single-cell RNA-seq results have defined transcriptome signatures of spermatogonial stem cells (SSCs) that discriminate these cells from all other spermatogenic cell types in the adult mammalian testis. We hypothesize that spatial genomic detection of this SSC signature in tissue sections will reveal the location of mammalian SSCs.
