The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Jiang, Jean X
Funded by
NIH-ARTHRITIS/MUSCULOSKEL/SKIN DISEASES
Collaborating Institutions
University of Incarnate Word
Mechanical loading experienced by skeletal tissues plays an important role in bone formation and remodeling.Osteocytes are the most abundant bone cell type and the major mechanosensory cells of the bone. Theyorchestrate bone remodeling from their location throughout bone matrix by coordinating osteoblastic formationand osteoclastic resorption. Osteocytes are connected to neighboring osteocytes and other bone cells via gapjunction channels and to extracellular environments via hemichannels. Both types of channels are formed byconnexin (Cx) 43.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Lehman, Donna M
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Collaborating Institutions
Chicago UTRGV
Translating information on genetic risk for body weight regulation into molecular mechanisms can have asignificant impact on intervention and therapies. We are seeking to identify genetic variation and theirmolecular mechanisms that influences obesity through direct effects on the hypothalamus as it is the brain hubthat regulates energy homeostasis and there is now considerable evidence for genetic influence to impact thisbrain region.
