The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Li, Rong
Funded by
NIH-NATIONAL CANCER INSTITUTE
Estrogen receptor (ER)? exhibits an antitumor activity in multiple cancer types in both tumor-intrinsicand -extrinsic manners. However, little is known as to how such activity can be harnessed with high efficacyand precision, nor is it clear which host cell type(s) mediates the tumor-extrinsic function of ER?. These majorknowledge gaps hamper efforts to unleash ER? antitumor activity for cancer therapies. We recently discovereda phosphotyrosine-dependent signaling axis that controls ER? antitumor activity.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Boyer, Thomas G
Funded by
NIH-NATIONAL INST OF CHILD HEALTH AND HU
Collaborating Institutions
UnivChicago
Uterine fibroids (UFs; leiomyomas) are the most important benign neoplastic threat to women's healthworldwide, but disproportionately affect women of color, particularly African American (AA) women, who have athreefold higher incidence rate and relative risk of UFs than Caucasian (CC) women. While the underlyingcause for this risk disparity is not fully understood, recent studies implicate hypovitaminosis D as a majorcontributor.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC) provides support for research conducted by investigators and their collaborators addressing the unique scientific needs of the Air Force, the Department of Defense and the Nation.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Walter, Christi A
Funded by
NIH-NATIONAL INSTITUTE ON AGING
Children with a genetic disease or birth defect are hospitalized at a younger age, stay longer, and have ahigher death rate than children hospitalized for other reasons. One in 33 infants born in the US has a birthdefect; the number one cause of infant mortality. Our long-term goal is to change these dire statistics bydelineating the mechanisms that reduce game quality by increasing mutagenesis in male gametes withincreasing age, i.e., the paternal age effect.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Paukert, Martin
Funded by
NIH-NATL INSTITUTE OF MENTAL HEALTH
Awake behavior is accompanied by fluctuations in vigilance shaping the overall activity state of the brain tooptimize cellular and circuit activity. The cellular and molecular mechanisms for such brain state-dependentadjustments in neural activity are not well understood. Using a mouse locomotion paradigm we have recentlyfound that the transition from a resting state to active locomotion is associated with release of theneurotransmitter norepinephrine and leads to Ca2+ activation of astroglia.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC) provides support for research conducted by investigators and their collaborators addressing the unique scientific needs of the Air Force, the Department of Defense and the Nation.