As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Leopold Wager, Chrissy M
M. tuberculosis, which causes the worldwide global health problem tuberculosis (TB), is transmitted human to human via the airborne route into lung alveoli and ultimately exploits and grows in host macrophages. We seek to understand the cell signaling pathways initiated by infection of human macrophages with M. tuberculosis that lead to disease. Increased understanding of how macrophages are susceptible to M. tuberculosis is expected to aid in the development of host-directed therapies for TB.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Apicella, Alfonso
Muzzio, Isabel
Funded by
Natl Inst of Health
Cortical function is characterized by the dynamic interplay of two major forces: excitation and inhibition. A current belief is that dysfunction of inhibition. mediated by local GABAergic interneurons. leads to a wide range of neurological diseases such as epilepsy. autism. schizophrenia. PTSD. A well-established principle of the cortical circuit organization is that inhibition is local while excitation is both local and long-range; however. this ignores that inhibition may be long-range as well.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Carrion, Ricardo
Funded by
National Institutes of Health
Collaborating Institutions
BioCryst Pharmaceuticals
Inc
The overall goal is to evaluate the potential treatment efficacy of IV-dosed galidesivir.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Martinez-Sobrido, Luis
Collaborating Institutions
University of Texas Health Science Center San Antonio
Exploiting the Viral RNA Methylation Machinery for SARS-CoV-2 Therapy
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Hayhurst, Andrew
Funded by
National Institutes of Health
Unique proteins and peptides can transform salt solutions into crystals visible to the naked eye. The goal if this project is to couple these motifs to small antibodies that recognize repetitive components of pathogens so that the presence of a microbe will be signaled by the appearance of a crystal. This process could lead to the development of a new generation of inexpensive and easy to use point-of-care tests for diseases that will advance human healthcare.
