The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Sharma, Kumar
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Acute kidney injury (AKI) and chronic kidney disease (CKD) are major contributors to overall morbidity andmortality in patients in the US. The overall objective of the proposed study is to establish untargeted andtargeted spatial metabolomics analysis of tissues from normal and diseased kidneys to assess cellularmetabolic states associated with healthy function, acute injury, chronic condition, and recovery.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Strong, John R
Funded by
NIH-NATIONAL INSTITUTE ON AGING
Identification of small molecules that extend mouse lifespan provides new insights intomechanisms of longevity determination in mammals, and may lay the groundwork for eventualanti-aging therapies in humans. The NIA Interventions Testing Program (ITP) evaluates agentsproposed to extend mouse lifespan by retardation of aging or postponement of late lifediseases.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ivanov, Dmitri N
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
SAMHD1, a mammalian member of the HD-domain hydrolase family of enzymes, catalyzes hydrolysis ofdeoxynucleotides triphosphates (dNTPs) to triphosphate and unphosphorylated nucleosides, which is thoughtto be the main pathway for controlled depletion of cellular dNTPs. Discoveries that SAMHD1 is an immunefactor that restricts retroviral replication in non-cycling immune cells and regulates interferon signaling revealedthat dNTP depletion may act as a defense mechanism of innate antiviral immunity.
