As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Kaushal, Deepak
Funded by
National Institutes of Health
Collaborating Institutions
University of Washington
The major goal is to study the role of ILC3 type cells in the mucosal immunity to Mtb infections in macaques. Role: Sub-PI
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Kaushal, Deepak
Funded by
National Institutes of Health
Collaborating Institutions
Emory University
19-053 The major goal is to develop reagents for and to identify antigen-specific T cell responses in macaques with persistent and cured LTBI. In the first three years of this program project we have infected 12 macaques with ultra low-dose of Mtb to generate LTBI, and developed a model for LTBI clearance by treating half the animals with INH/RIF weekly regimen for 12 weeks. We will now study correlates of clearance in INH/RIF treated and untreated animals using banked PBMCs, stimulated BAL and lung cell samples.
