This proposal seeks support for the South Texas Medical Scientist Training Program (STX MSTP) at theUniversity of Texas Health Science Center at San Antonio (UTHSCSA), a federally designated Hispanic-servinginstitution in a minority-majority city. As national leader in clinical and translational research on Hispanic,military, and Veteran health issues, UTHSCSA addresses regional health disparities that present both challengesand opportunities for medical research that are of nationwide relevance.

Cognitive impairment has a serious detrimental impact on the quality of life for prostate cancer survivorstreated by androgen deprivation therapy (ADT). Neuroimaging studies have shown structural and functionaldeficits in the medial prefrontal cortex (mPFC) and hippocampus (Hipp), which mediate higher order cognitiveprocesses, including cognitive flexibility and spatial cognition, that are impaired after ADT. In this project, we willinvestigate mechanisms that underly the cognitive impairments we have now shown to be induced by androgendeprivation in rats.

Stimulant abuse is a serious public health problem with untold medical, societal, and economic impactworldwide. Despite decades of research into the neurobiology of drug abuse, there are no FDA-approvedpharmacotherapies for stimulant abuse. One strategy to reduce the time required to get candidate medicationsinto the clinic is to repurpose drugs, already approved by the FDA for other indications, to treat stimulant abuse,and one strategy to improve the therapeutic effectiveness of a drug is to administer it in combination with seconddrug with a complimentary mechanism of action.

This contract evaluate biological membrane composition and functional protein presence and activity with the goal of developing products for tissue regeneration.

The major goal is study if multiple antigen presenting system (MAPS) can effectively boost BCG vaccination responses to protect macaques against lethal Mtb challenge. Role: Sub-PI

19-053 The major goal is to develop reagents for and to identify antigen-specific T cell responses in macaques with persistent and cured LTBI. In the first three years of this program project we have infected 12 macaques with ultra low-dose of Mtb to generate LTBI, and developed a model for LTBI clearance by treating half the animals with INH/RIF weekly regimen for 12 weeks. We will now study correlates of clearance in INH/RIF treated and untreated animals using banked PBMCs, stimulated BAL and lung cell samples.