The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Sharma, Kumar
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Collaborating Institutions
EMBL PNNL USCD
Acute kidney injury (AKI) and chronic kidney disease (CKD) are major contributors to overall morbidity andmortality in patients in the US. The overall objective of the proposed study is to establish untargeted andtargeted spatial metabolomics analysis of tissues from normal and diseased kidneys to assess cellularmetabolic states associated with healthy function, acute injury, chronic condition, and recovery.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC) provides support for research conducted by investigators and their collaborators addressing the unique scientific needs of the Air Force, the Department of Defense and the Nation.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Awad, Alaa S
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Diabetes mellitus (DM) is a global health problem. The prevalence of diagnosed and undiagnosed diabetes in the US is progressively increasing from 7.8% in 2007, 14.5% in 2010 and expected to rise between 24.7% to 32.8% in 2050. Diabetes is the most common cause of end stage renal disease, responsible for more than 40% of all cases in the US, and this number are likely to continue to increase unabated. Endothelial cell dysfunction is a central pathophysiological mechanism that contributes to diabetes and diabetic nephropathy (DN).
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Abdul-Ghani, Muhammad A.
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Sodium-Glucose cotransport inhibitors (SGLT2i) are a novel class of antidiabetic agentswhich lower the plasma glucose concentration by inhibiting renal glucose reuptake andproducing glucosuria.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Liu, Feng
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Mitochondria in hepatocytes play a major role in maintaining whole-body energy metabolism and normalfunction of the liver. Impaired mitochondrial function is closely associated with various metabolic diseases suchas obesity, insulin resistance, and hepatosteatosis. However, the precise underlying mechanisms remain to befully elucidated.