Objective: Analyze doramectin levels in serum samples from cattle treated in the field to study the interaction between a 1% doramectin product and Bm86 vaccination against fever ticks. Approach: Blood samples collected during the field study will be processed at the USDA, ARS, Cattle Fever Tick Research Laboratory (CFTRL) to obtain serum. ARS will provide the serum samples to The University of Texas at San Antonio (UTSA) to conduct the analysis per the one year field study as detailed below. The serum samples will be shipped to UTSA for analysis to determine doramectin levels.

Objective:

Complete concentration analysis of eprinomectin in serum obtained from blood samples collected at the USDA, ARS, Cattle Fever Tick Research Laboratory (CFTRL) in collaboration with the ARS scientists in support of the continuation of research studying the interaction between the Bm86 vaccine and a long-acting eprinomectin injectable formulation.

Approach:

Enterohemorrhagic Escherichia coli (EHEC) of the O157:H7 serotype are notorious for the producing
 highly potent Shiga toxin. which is a direct mediator of life-threatening global human disease. In this proposal.

The goal is to Develop treatments for Zika infection during pregnancy using a marmoset model.

HIV is a major worldwide challenge that remains to be solved, and there is a continuous need to identify improved preventative and therapeutic interventions. This annual symposium provides an environment that promotes the exchange of ideas and perspectives, and fosters new collaborations, especially between junior and senior members of the research community.

The major goal is to assess the ability of Mtb-specific CD4 T cells from ART versus ART + IPT animals to active antimicrobial functions of Mtb-infected macrophages. Role: PI

Proposal:19-051 The major goal of this proposal is to vaccinate neonatal macaques with recombinant, TLR-2 stimulating, BCG vaccine, which can induce central memory T cells, and thereby generate long-term immunity against tuberculosis. We will, therefore: 1) Evaluate TH1 immune responses induced by wild type and recombinant BCG vaccine in neonatal macaques; 2) evaluate efficacy of wild type and recombinant BCG vaccines against tuberculosis in neonatal macaques; and, 3) evaluate long-term efficacy of wild type and recombinant BCG vaccines using in neonatal macaques. Role:Co-PI

The major goal of this project is to perform screening EBOV ELISA assay for 30 cynomolgus samples from Covance for UTMB.

Artemisinin is the endoperoxide-containing plant natural product used to treat malaria, a deadly disease that has killed 445,000 people in 2016 - 90% of these deaths were in Africa. The current industrial production of artemisinin employs a semi-synthetic approach, which involves the microbial fermentation of yeast containing the plant genes to produce the biosynthetic precursor, artemisinic acid, followed by four chemical transformations to yield artemisinin.

The major goal is to develop a delta-sigH -based human TB vaccine candidate that could eventually advance to clinical development. Role: PI