TxBiomed is processing Luminex assays for a service fee.

The Subcontractor shall furnish the necessary ABSL-4 non-human primate facility equipment and caging, management oversight and personnel for the performance of laboratory animal support services, and select BSL4 challenge material (filoviruses e.g. Ebola, Marburg) to test various novel compounds against filovirus infection.

TxBiomed will furnish the necessary services, qualified personnel, material, equipment and facilities to perform vaccine testing using the Sudan GP virus.

Mining recombinant antibody libraries for binders that function well together in an immunoassay is a critical component of developing diagnostics for infectious disease agents and assays for host biomarkers to study disease processes. While identifying antibodies that bind the antigen of interest is reasonably straightforward, combining them in a sandwich assay demands protein purification and in vitro modification, processes that rapidly escalate costs and time when pairing hundreds of potential clones.

The goal of this project is to piece together an effective HIV vaccine using the Simian Immunodeficiency Virus and the Varicella virus.

The goal of the program described here is to develop an antiviral drug for treating and preventing Lassa fever and other hemorrhagic fevers of arenavirus origin.

Schistosome parasites vary in biomedically important traits including virulence, host specificity, and resistance to drug treatment. We aim to develop efficient, economical methods for genetic mapping in S. mansoni that are applicable to a wide range of biomedically important traits.

The mission of the TxBiomed component is to generate the Marburg virus and propagate it, determine the virus' consensus sequence, experimentally determine the LD50 of guinea pig adapted Angolan Marburg virus, and evaluate the immunogenicity and efficacy of Marburg and Ebola Zaire VLPs monovalent vaccines when administered in two different adjuvants to guinea pigs and Non-Human Primates.

STDs and unwanted pregnancy create tremendous burdens on individuals, on U.S. society, and on the national health care costs. The work in this project will provide new approaches for preventing and treating STDs and preventing unwanted pregnancy. Specifically, we will test a new approach for treatment of HIV/AIDS infections. The approach will emphasize materials and approaches that can be translated into clinical products, which would provide new opportunities for enhancing health.

Malaria is major public health problem, causing over 1 million deaths per year worldwide. The discovery and development of new antimalarial drugs is becoming increasingly urgent as drug- resistant strains become increasingly prevalent. We propose to isolate the active antimalarial compound(s) present in the crude extracts in at least 14 previously uninvestigated plants that have promising antimalarial activity.