This competing renewal application requests a second five-year support by the Ruth Kirschstein NationalResearch Service Award (T32) for our ?Cancer Biology Training Program? based at the University of TexasHealth Science Center at San Antonio (UTHSCSA), a Hispanic-Serving Institution.

As of 2014, there are approximately 14.5 million cancer survivors within the United States and this populationis projected to grow to 19 million by 2024. Cancer survivors exhibit an accelerated aging phenotype that ishypothesized to be a result of their exposure to chemotherapy. Despite the preponderance of evidencesuggesting that this accelerated aging phenotype happens, there are few basic science initiatives poised tostudy the underlying molecular mechanisms and their therapeutic implications.

Cocaine use disorder is a chronic disease that takes a huge toll on society, and there is currently a lackof understanding of the cellular and circuit adaptations that take place in response to contingent drug use.While studies have examined excitatory signaling, there has been less focus on inhibitoryneurotransmission in brain regions that play a central role in addictive behaviors.

The consumption of 3 fatty acid-rich foods is associated with multiple health benefits, including theprevention of cardiovascular and neurologic diseases. However, while the dietary consumption of these fattyacids often shows benefits, the use of fish-oil containing capsules and other supplements to augment theintake of ?-3 fatty acids has produced largely negative results on these health outcomes in clinical trials.