The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Lococo, Peter
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Type 2 diabetes (T2D) afflicts nearly 30 million individuals in the US, with at least 50% suffering from neurologicalcomplications that comprise diabetic neuropathy (DN). The metabolic changes in T2D produce substantialperipheral nerve damage that manifests commonly as debilitating numbness and neuropathic pain. Progressionof the nerve damage often leads to loss of sensation that can compromise patients? ability to execute daily tasksand care for themselves, while also increasing risk of severe injury.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Zang, Mengwei
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
The major goal of this project is to understand how the NAD+-dependent deacetylase SIRT1 regulateshepatokines that are secreted by the liver and how this process slows the progression of non-alcoholic fatty liverdisease (NAFLD) and obesity. Obesity or being overweight affects approximately 70% of U.S. adults andincreases the prevalence of developing NAFLD and Type 2 diabetes. Type 2 diabetes is a life-threateningdisease characterized by peripheral insulin resistance, which dysregulates inter-tissue communication topromote hyperglycemia and dyslipidemia.
