The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Xiong, Na
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
Collaborating Institutions
PNNL
BATTELLE
EMBL
The skin is the outmost epithelial tissue of a body that is under frequent assaults ofenvironmental agents. To protect against the assaults and maintain the local tissueintegrity, immune cells need to be properly positioned in the skin. A group of immunecells, namely innate lymphoid cells (ILCs), are preferentially localized in the skin wherethey function as the first line of defense but can also contribute to the skin inflammatorydiseases such as topical dermatitis and psoriasis when dysregulated.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Han, Xianlin
Funded by
NIH-NATIONAL INSTITUTE ON AGING
Aging is the greatest known risk factor for Alzheimer's disease (AD), the most common cause of dementia inolder individuals. However, effective AD therapies remain elusive, which underscores the need to betterunderstand disease etiology and its co-occurrence with advanced age. The apolipoprotein E4 (apoE4) allele isthe strongest genetic risk factor for late-onset AD and it is associated with decreased lifespan. The apoEprotein is crucial to lipid homeostasis through its regulation of cholesterol, triglyceride and phospholipidmetabolism in the blood and the brain.
