In this multidisciplinary proposal we will use a nonhuman primate model of Parkinsons disease to study the reversibility of the beneficial effects of physical exercise and its impact on induced pluripotent stem cell (iPSC)-based therapy. We will investigate how exercise and iPSC-based cell therapy reinnervate the striatum and restore movement and gait by recruiting new neural networks as revealed by longitudinal multimodal imaging, behavioral and morphological analysis.

The major goal of the project is to evaluate efficacy of new therapeutics for filoviruses (e.g. Zaire ebolavirus, Sudan ebolavirus, Marburg virus) in lethal intramuscular challenge non-human primate models.

The objective of this task is to evaluate efficacy of new therapeutics for EBOV in a lethal intramuscular challenge nonhuman primate models

The goal is to investigate the molecular basis of the functional impact of HIV-Tat protein binding cellular LncRNAs on HIV replication. Outcomes from the study outlined in this proposal will likely provide new functional insights into how the interaction between cellular LncRNAs and HIV proteins contributes to HIV pathogenesis and host defense, and identify novel molecular mechanisms of gene regulation, as well as therapeutic targets.

This project seeks to find novel molecular parameters of disease in Kawasaki disease. We will collaborate with UTSA and UTHSCSA for help with proteomic analysis and mouse echocardiograms. Using proteomics, we will correlate histologic disease and cardiac function with protein signatures of disease. This is a 1 year project.

This is to do one mouse experiment to evaluate a small molecule inhibitor.

We will be responsible for BSL4 experiments involving Ebola virus infection of treated and untreated murine macrophages.

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We have discovered that human APOBEC3 genes produce enzymes with different sizes and activities in different human populations. Importantly, the mutations induce, by APOBEC3 enzymes, in the HIV-1 genome also have distinct patterns in different human populations. The major goals of this study are to establish association between genetic variations in the APOBEC3 locus and variations in HIV-1 hypermutation patterns, and determine the underlying molecular mechanisms.

The major goals of this project is to determine the mechanisms used by M.tb to persist in the macrophage environment via its activation of host PPAR?. The studies herein represent the next steps to elucidating the role of eicosanoids, critical players at the interface of inflammation and metabolism, in M.tb survival and growth and provide a foundation for the transition to in vivo models of TB. Txbiomed Project: 4692