As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Kadosh, David
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
Collaborating Institutions
USC UTSA
Candidiasis has remained the most common opportunistic oral infection in HIV positive individuals and AIDSpatients. Even following the introduction of highly active antiretroviral therapy (HAART) approximately 30% ofAIDS patients acquire oropharyngeal candidiasis (OPC). Candida albicans, the main causative agent of OPC,forms complex aggregated microbial communities, known as biofilms, on host oral mucosal surfaces whichplay an important role in establishing infections called ?oral thrush?. C.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Zhang, Nu
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
Infectious diseases pose a significant public health burden, accounting for nearly one-fifth of deaths globallyper annum. Most infections are initiated from a restricted mucosal tissue, such as the intestine. To fightintestinal infections, gut-resident immune cells are superior to circulating ones. There is a surge of recentinterest in tissue-resident memory T (TRM) cells that have been shown to be a critical adaptive immunecomponent of mucosal immunity. These cells have been flagged as an ideal cell population to be generated inT cell-based vaccines.
